Mks6/Cc2d2a and Tctn1 are embryonic lethal, and have similar severity of, and timing of, phenotypes such as microphthalmia (E14.5), HH signaling defects such as exencephaly (E11.5) and polydactyly (E14.5), and LR asymmetry defects (Garcia-Gonzalo et al., 2011; Lewis et al., 2019). Here, CC2D2A is linked to microphthalmia.