Blocking of the astrocytic calcium channel Transient Receptor Potential Ankyrin 1 (TRPA1) or the enzyme epoxide hydrolase, which is predominantly expressed by astrocytes, have both been shown to normalise astrocytic activity, prevent neuronal dysfunction and improve cognitive function in AD mouse models (Ghosh et al., 2020; Paumier et al., 2022). This evidence concerns the gene TRPA1 and Alzheimer disease.