Aβ, a type of polypeptide that is hydrolyzed from amyloid precursor protein using β and γ secretory enzymes in a cascade, participate in the pathological progress of amyloidosis because of misfolding of the extracellular protein accumulated in senile plaques, and intraneuronal Aβ42 accumulation is more common than Aβ40 among them(Chen et al., 2017; John and Reddy, 2021). This evidence concerns the gene APP and amyloidosis.