After synthetically analyzing the perioperative factors including age, sex, hypertension, diabetes, coronary heart disease, drinking history, smoking history, education years, preoperative MMSE score, preoperative MoCA score, preoperative PSQI score, Aβ40, Aβ42, T-tau, P-tau, Aβ40/Aβ42, T-tau/P-tau, Aβ40/T-tau, Aβ42/T-tau, and Aβ42/P-tau, we performed multivariate regression analyses for POD. The gene discussed is MAPT; the disease is hypertensive disorder.