AGT and hypertensive disorder: On the contrary, under pathological conditions associated with the RAS overactivation, such as hypertension, atherosclerosis, myocardial infarction (Steinberg et al., 1989; Dhalla et al., 1996), diabetes (Rincon-Choles et al., 2002), and aging (Baylis et al., 1997; Thompson et al., 2000; Wang et al., 2003), the dysregulation of Ang II-dependent ROS generation may become a critical contributor to cell oxidation and connective tissue damage.