AGT and heart failure: Furthermore, ACE2 transforms Ang I into angiotensin-(1–9) [Ang-(1–9)] that, through the activation of angiotensin type 2 receptor (AT2R), may decrease blood pressure and protect the heart, blood vessels and possibly the kidney from adverse cardiovascular remodeling stimulated by hypertension or heart failure (Donoghue et al., 2000; Shariat-Madar and Schmaier, 2004; Ocaranza et al., 2014).