BACE1 and Alzheimer disease: The APP is usually cleaved by the enzyme α-secretase (ADAM10), generating soluble peptides (APPs); in AD, an alternative and sequential cleavage of APP occurs by secretases β (BACE-1) and y, generating insoluble Aβ peptides that aggregate and deposit in the extracellular space, triggering several pathological events that cause neuronal death and formation of senile or neuritic plaques (NPs).