The APP is usually cleaved by the enzyme α-secretase (ADAM10), generating soluble peptides (APPs); in AD, an alternative and sequential cleavage of APP occurs by secretases β (BACE-1) and y, generating insoluble Aβ peptides that aggregate and deposit in the extracellular space, triggering several pathological events that cause neuronal death and formation of senile or neuritic plaques (NPs). Here, APP is linked to Alzheimer disease.