31 Trinh Trinh NH NH Hoblyn Hoblyn J J Mohanty Mohanty S S Yaffe Yaffe K K Efficacy of cholinesterase inhibitors in the treatment of neuropsychiatric symptoms and functional impairment in Alzheimer disease: a meta-analysis Efficacy of cholinesterase inhibitors in the treatment of neuropsychiatric symptoms and functional impairment in Alzheimer disease: a meta-analysis JAMA JAMA 2003 2003 289 289 2 2 210 210 216 216 10.1001/jama.289.2.210 10.1001/jama.289.2.210 12517232 12517232. This evidence concerns the gene BCHE and early-onset autosomal dominant Alzheimer disease.