Although genome-wide association studies failed to identify RHOT1 (the gene encoding Miro1) as a risk locus for Parkinson’s disease (PD) (Anvret et al., 2012; Saeed, 2018; Nalls et al., 2019), rare RHOT1 variants identified by exome sequencing (Berenguer-Escuder et al., 2019; Grossmann et al., 2019) have provided insight into the complex biology of PD. The gene discussed is RHOT1; the disease is Parkinson disease.