Furthermore, Lu et al. found that treadmill exercise increased interleukin 4 (IL-4) expression, decreased markers of pro-inflammatory M1 cells in microglia, and increased characteristics of anti-inflammatory M2 cells to inhibit M1 microglia and promoted M2 microglia activation, thereby suppressing the inflammatory response during the stroke (Lu et al., 2021b). The gene discussed is IL4; the disease is stroke disorder.