While our previous studies show that SRC activation suppresses inflammatory signaling (Coste et al., 2006; Yu et al., 2007; Chen Q. et al., 2010; Mullany et al., 2021), these results suggest 10-1 also provides neuroprotection by promoting early microglial activation in the acute tissue response (up to 48 h after stroke). Here, SRC is linked to stroke disorder.