KALRN and Global developmental delay: Recent exome sequencing studies [reviewed in Parnell et al. (2021)] have isolated a range of mutations that disrupt Kalirin expression or function and potentially contribute to neurodevelopmental disorder risk, such as ASD (Leblond et al., 2019; Satterstrom et al., 2020), schizophrenia (Kushima et al., 2012; Purcell et al., 2014; Howrigan et al., 2020), and developmental delay/ID (Makrythanasis et al., 2016; Deciphering Developmental Disorders Study, 2017).