CD274 and non-small cell lung carcinoma: PD-L1 is known target for most of the ICIs in use as monotherapies, therefore the impact of PD-L1 expression differences between individuals on the trials involving ICIs and PARPi was probed in an interventional JASPER phase II study [NCT03308942]2 tested the combination of niraparib and pembrolizumab or dostarlimab on a group of chemotherapy-naïve patients with locally advanced or metastatic NSCLC with no prior PD-(L1) chemotherapy.