Furthermore, GNAO1 is closely related to epileptic encephalopathy and neurological dysfunction (Feng et al., 2017), PRKCB exerts a regulatory effect on neuronal function (Antonell et al., 2016), and GRIA2 is closely related to status epilepticus and depression (Gasparini et al., 2014). The gene discussed is GNAO1; the disease is depressive disorder.