Furthermore, GNAO1 is closely related to epileptic encephalopathy and neurological dysfunction (Feng et al., 2017), PRKCB exerts a regulatory effect on neuronal function (Antonell et al., 2016), and GRIA2 is closely related to status epilepticus and depression (Gasparini et al., 2014). This evidence concerns the gene GNAO1 and depressive symptom measurement.