HOTAIR and cancer: LncRNA associated DNA methylome deviation is achieved through direct or indirect interactions with DNMT or TET members to recruit or sequester these enzymes from specific genome loci, resulting in promotion or repression of the DNA methylation in cis or in trans. HOTAIR and some other lncRNAs, such as particle, are found to recruit epigenetic modifiers to RNA binding loci in the genome by formation of triple helix, which functions to modulate global methylation in cancer cells (Kalwa et al., 2016; O'Leary et al., 2017).