LRIG1 and acute myeloid leukemia: In AML, MAGI2-AS3 recruits TET2 to the LRIG1 promoter region in trans and causes DNA demethylation of LRIG1. Downregulation of MAGI2-AS3 suppresses the self-renewal capacity of leukemic stem cell by promoting LRIG1 expression (Chen et al., 2020).