DNMT3A and Familial prostate cancer: For example, lncRNA SChLAP1 was found to recruit EZH2 and DNMT3A to repress multiple miRNA expression in prostate cancer, including the miR-340-5p/miR-143-3p/miR-145-5p, these miRNAs in turn regulate DNMT3A expression (Huang and Tang, 2021).