LncRNA HOTAIRM1 (HOX antisense intergenic RNA myeloid 1), which is located between the HOXA1 and HOXA2 genes, could interact with DNMTs and other epigenetic factors to sequester them away from HOXA1 promoter in glioblastoma multiforme (GBM). The gene discussed is HOXA2; the disease is glioblastoma.