This has been confirmed by the interaction between lncRNA SNHG6 and MAT family members of MAT1A and MAT2A. On one hand, SNHG6 was found to upregulate MAT2A expression by act as sponge for miR-1297, on another hand, this lncRNA also downregulate MAT1A translation by suppressing the nucleus-cytoplasmic shuttling of MAT1A mRNA, thereby regulate genome wide methylation in hepatoma cells of HCC (Guo et al., 2018). This evidence concerns the gene MAT2A and hepatocellular carcinoma.