Furthermore, peiminine mediates cell cycle arrest by inhibiting Akt/glycogen synthase kinase 3 beta (GSk3β) and AMP-activated protein kinase (AMPK)/autophagy-activating kinase (ULK1) signaling, which leads to reduced autophagic flux, thereby slowing tumor growth down (Zhao et al., 2018). This evidence concerns the gene GSK3B and neoplasm.