In another study, we observed that P2Y4 KO mice are protected against myocardial infarction: they display smaller infarcts in the left anterior descending coronary artery ligation model (LAD ligation model), as well as a significant decrease in cardiac inflammation and permeability (Horckmans et al., 2015). The gene discussed is P2RY4; the disease is myocardial infarction.