NPPB and coronary artery disorder: Regarding markers of cardiac function, the resting heart rates were lower in CAD patients carrying the N178T variant (Table 4, 55.5 ± 3.4 versus 64.6 ± 1.5 bpm in WT; mean ± SEM, p = 0.015) as well as the plasma level of NT-proBNP (Figure 2D; Table 4, 177.6 ± 56.3 versus 493.3 ± 89.1 pg/ml in WT; mean ± SEM, p = 0.004).