NR3C1 and major depressive disorder: Depression increases levels of inflammatory cytokines at baseline, and cytokines modulate the hypothalamic-pituitary-adrenocortical (HPA) axis, which ultimately results in increased production of corticotropin-releasing hormone and glucocorticoid receptor resistance (Costa et al., 2020); and diminution of negative feedback at glucocorticoid receptors results in dysregulation of proinflammatory response.