Lee et al., 2018 study showed that phenols, saponins and protodiosgenin in A. cochinchinensis extracts induced enhanced nerve growth factor secretion and decreased intracellular ROS in neurons and microglia cell lines, inhibiting the activity of acetylcholinesterase, thereby improving Alzheimer’s disease (Lee et al., 2018). This study provides novel directions for developing new drugs from A. cochinchinensis, and, more importantly, offers new insights into the treatment of Alzheimer’s disease. Here, ACHE is linked to early-onset autosomal dominant Alzheimer disease.