NPPA and heart failure: In addition, ginsenoside Rbl can improve cardiac function and remodeling in patients with heart failure, and the mechanism may be that ginsenoside can not only reduce β-myosin heavy chain (βMHC), angiotensin I converting enzyme (ACE), angiotensin II (AngII) and atrial natriuretic factor (ANF), but also regulate mitochondrial membrane potential (Zheng et al., 2017b).