According to reports, TP53 is frequently mutated in UC and colorectal neoplasia that develop from UC, over 50% of colitis-induced colorectal cancer and colon neoplasia could be found with the TP53 mutation (Mäki-Nevala et al., 2021; Matsumoto et al., 2021; Arai et al., 2022). The gene discussed is TP53; the disease is colitis.