Similarly, researchers utilized superparamagnetic iron oxide-based NPs (SPIONs) combined with chitosan lactate (CL) and folic acid (FA) nanoparticles (NPs) loaded with TIGIT-siRNA and HIF-1α-siRNA for suppressing TIGIT and HIF-1α in tumor cells in another study. The gene discussed is HIF1A; the disease is neoplasm.