In order to improve the antitumor activity of BA, researchers prepared polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol (PVCL-PVA-PEG) grafts Copolymer (Soluplus) encapsulated BA micelles, which inhibit the angiogenesis of BC cells by suppressing the HIF-1/VEGF/FAK signaling pathway (Qi et al., 2021). This evidence concerns the gene HIF1A and breast cancer.