A polyvinyl caprolactam–polyvinyl acetate–polyethylene glycol (PVCL–PVA–PEG) graft copolymer (Soluplus) encapsulated BA micelle (Soluplus-BA) was fabricated and results showed that Soluplus-BA micelles increased the inhibitory effect of BA on the angiogenesis by regulating the HIF-1/VEGF-FAK signaling pathway in breast cancer MDA-MB-231 cells (Qi et al., 2021). Here, HIF1A is linked to breast cancer.