YAP1 and glioblastoma: In this study, we provided evidences that irigenin inhibited the proliferation and migration of GBM cells, induced G2/M phase arrest, and regulated apoptosis-related signaling molecules to promote apoptosis by inhibiting YAP/β-catenin signaling, which suppressed the progress of GBM in vivo and in vitro progress as the working model shown (Figure 9).