YAP1 and cancer: In addition, the nuclear localization of YAP1 was increased in various cancer tissues and the regulation of YAP1 translocation between the cytoplasm and nucleus is a key step in hippo signaling, which is critical for physiological cell proliferation, organ size and tumor development (Huang et al., 2005; Zeng and Hong, 2008; Vlug et al., 2013; Fang et al., 2018).