Western blotting further showed the relative protein level of p-YAP/YAP was increased in these irigenin-treated GBM cells (Figures 5D,F; Supplementary Figure S2G, J,K), similarly, the relative level of upstream regulatory protein p-MOB1/MOB1 was also increased (Figures 5D,E; Supplementary Figure S2G–I). The gene discussed is YAP1; the disease is glioblastoma.