Molecular signaling pathways that are known to be well studied in the carcinogenesis and progression of glioma, including Hippo/YAP, Wnt/β-catenin, STAT and Notch pathways (Zhang et al., 2012; Swiatek-Machado and Kaminska, 2013; Yan et al., 2018; Ouyang et al., 2020; ). This evidence concerns the gene YAP1 and central nervous system cancer.