YAP1 and glioblastoma: In this study, we focused on the effects of irigenin on GBM cells and the underlying signaling pathway, and found that irigenin inhibited the proliferation and migration of GBM cells, caused cell cycle arrest at G2/M phase, and induced apoptosis of GBM cells, and finally found that irigenin inhibited the progression of GBM both in vitro and in vivo through suppressing YAP/β-catenin pathway.