In gastric cancer cells, irigenin sensitizes TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by enhancing the expression of pro-apoptotic molecules in the cells, as evidenced by elevated expression of Bcl-2, Caspase-3, and Caspase-8, and in order to make TRAIL produce ROS(Xu et al., 2018). This evidence concerns the gene CASP8 and gastric cancer.