Further study found that Spi exhibits significant anti-proliferative effects on glioma cells in both in vitro and in vivo models by decreasing the expression of PI3K/AKT/mammalian target of rapamycin (mTOR) and increasing the expression of miR-34a and miR-125b (Arab et al., 2021; Braune et al., 2021). Here, MTOR is linked to glioma.