E2F3 and neoplasm: The molecular mechanism of shrimp miR-34 against human tumors was shown to be related to shrimp miR-34-mediated expression of multiple human tumor-related genes, including cyclin D1 (CCND1), cyclin dependent kinase 6 (CDK6), cyclin E2 (CCNE2), E2F transcription factor 3 (E2F3) FOS-like antigen-1 (FOSL1), and hepatocyte growth factor receptor (MET) (Cui et al., 2017), while the tumor suppressor function of mja-miR-35 is achieved by targeting M2 macrophages and human chitinase-3-like protein 1 (CHI3L1) (Chen et al., 2018b).