Downregulation of sodium/hydrogen exchanger 1 (NHE1), an isoform in the Na+/H+ exchanger family, was then found in miR-12462-overexpressing AML cells (Jia et al., 2020), while downregulation of ITGB3, c-MYC and BCL-XL was shown in let-7a-overexpressing AML cells (Chen et al., 2013b). This evidence concerns the gene BCL2L1 and acute myeloid leukemia.