Besides causing problems in the heart, enhanced RyR2 function is also involved in AD pathogenesis (Kelliher et al., 1999; Smith et al., 2005; Bruno et al., 2012; Oules et al., 2012; Chakroborty and Stutzmann, 2014; Lacampagne et al., 2017; SanMartin et al., 2017). Here, RYR2 is linked to Alzheimer disease.