In addition, Wang et al. indicated that the ARID5B SNPs were associated with higher MTX-PGs levels in B lymphocytes, which provides a possible explanation for the stronger response of B-ALL to MTX (Wang et al., 2020).Csordas et al. found that the ARID5B rs4948502, rs4948496, and rs4948487 were associated with MTX serum levels and there were significant associations between hepatotoxicity and the ARID5B rs4948502 in patients who received 5 g/m2 MTX (Csordas et al., 2014). The gene discussed is ARID5B; the disease is acute lymphoblastic leukemia.