AKR1C1 and cancer: Gagliardi et al. (2019) study showed that AKR1C1/3 degrades the 12/15-LOX-generated lipid peroxides, thus resulting in ferroptotic cell death resistance. It has been reported that AKR1C1 protects cancer cells from ferroptosis and is considered to be the ferroptosis-protective gene (Wohlhieter et al., 2020).