MAPT and Cognitive impairment: Improvement in cognitive impairment; Protein expression level (NeuN↑, PSD95↑, Aβ1-40↓, Aβ1-42↓, APP↓, hyperphosphorylated tau at the Thr217, Ser199/202 and Thr231, Ser396/404 sites↓, GLUT1↑, GLUT3↑); Restored impaired insulin signalling