The top 20 KEGG signalling pathways (Figures 7A,B) were the HIF-1 signalling pathway, lipid and atherosclerosis, AGE-RAGE signalling pathway in diabetic complications, Chagas disease, AD, pathways of neurodegeneration-multiple diseases, leishmaniasis, IL-17 signalling pathway, proteoglycans in cancer, prostate cancer, endocrine resistance, cellular senescence, C-type lectin receptor signalling pathway, human cytomegalovirus infection, Th17-cell differentiation, TNF signalling pathway, toxoplasmosis, tuberculosis, glioma, and pertussis. The gene discussed is HIF1A; the disease is Alzheimer disease.