Twelve strains were used: Wistar rats (n = 1), senescence-accelerated mouse strain prone 8 (SAMP8) mice (n = 3), hybridization between APP/PS1-21 mice and C57BL/6J mice (n = 1), APP/PS1 mice (n = 4), 3 × Tg-AD mice (n = 2), hybridization between 3 × Tg-AD mice and WT mice (n = 1), hybridization between Tg2576 mice and C57B6/SJL mice (n = 1), APPV717I mice (n = 1), SAMP10 mice (n = 1), SD rats (n = 6), hybridization between 5xFAD mice and B6/SJLF1 mice (n = 1), and C57BL/6 mice (n = 1). The gene discussed is APP; the disease is Alzheimer disease.