Improvement in cognitive impairment; Protein expression level (APP↓, Aβ1-42↓, LC3-II/LC3-I↓, Beclin1↓, Cat D↓, SOD↑, Cleaved-caspase-3↓, pS473AKT/AKT ratio↑, GFAP↓). This evidence concerns the gene MAP1LC3A and Cognitive impairment.