Improvement in cognitive impairment; Protein expression level (Aβ1-40↓, Aβ1-42↓, IL-1β↓); Inflammatory cytokines (IL-1β↓, TNF-α↓, IFN-γ↓, MCP-1↓, IL-17A↓, GM-CSF↓, IL-12p70↓, MCP-1↓, IL-10↑). The gene discussed is PPP1R3A; the disease is Cognitive impairment.