Improvement in cognitive impairment; Protein expression level (Aβ1-40↓, Aβ1-42↓, APP↓, BACE1↓, ADAM10↑); Inhibit ER stress in APP/PS1 mice by suppressing the PERK/eIF2α signalling pathway; Reduced apoptosis by ICA treatment mice was partly due to suppressed ER stress. This evidence concerns the gene EIF2AK3 and Cognitive impairment.