The use of panaxadiol saponins in severe acute pancreatitis can inhibit the expression of TNF-α and interleukin-6 (IL-6), reduce blood concentration, improve microcirculation, and upregulate the expression of AQP1 in lung tissue, thereby reducing pulmonary edema and lung injury (Zhao et al., 2009). The gene discussed is IL6; the disease is acute pancreatitis.