A first study has examined the transcriptome and miRNome profiles from the hippocampus of adult rats exposed to PNS with transcriptome data obtained from blood mRNA of adult humans exposed to early life trauma, demonstrating a strong interaction between TGF-β1 gene and PNS in the regulation of mechanisms relevant to stress and depression (Cattaneo et al., 2018). This evidence concerns the gene TGFB1 and depressive symptom measurement.