TGFB1 and Anxiety: Our data are in agreement with a study carried out by Trojan et al., where a deficit of TGF-β1 gene expression was found in hippocampus and frontal cortex of adult rats previously exposed to PNS during pregnancy, paralleled by anxiety and a depressive-like phenotype, which were normalized by a chronic antidepressant treatment (Trojan et al., 2017).