Ji et al. (2022) found that UDP-glycosyltransferase 8 (UGT8) enhanced tumor growth by promoting glycolysis in A549 cells, H460 cells, and a xenograft mouse model, and the depletion of UGT8 diminished tumor malignancy in vitro and in vivo. The depletion of PTEN-induced putative kinase 1 (PINK1) via shRNA in A549 cells suppressed tumor malignancy and increased the sensitivity of glycolysis inhibitor 3-BP by disrupting ATP production, promoting ROS generation, and inducing apoptosis (Dai et al., 2019). The glycolysis-related biomarkers reported earlier are summarized in Table 1 and Figure 2. This evidence concerns the gene PINK1 and neoplasm.