PKM2, which acts as a nuclear factor and participates in a metabolic loop with GLUT1 (Pan et al., 2019), is highly expressed in NSCLC and is potentially a specific target in treatment of NSCLC, according to data from nine patient-derived cell lines, two established cell lines (H1299 and H358), and nude mice (Suzuki et al., 2019). The gene discussed is PKM; the disease is non-small cell lung carcinoma.