Studies have shown that 12,13-DHOME comes from the oxidation of linoleic acid, which is related to an increased risk of ovarian cancer, cytochrome P450 monooxygenase oxidizes linoleic acid to produce 12,13-DHOME, the role of DHOME in multiple cellular functions may lead to an increased risk of ovarian cancer (Hada et al., 2019). Here, CYP20A1 is linked to ovarian cancer.