The findings from the raptor KO mice suggest that activation of mTORC1 in response to denervation serves to protect the muscle from severe atrophy; however, mice with chronic activation of mTORC1 (TSC1mKO) also show more severe atrophy following denervation, especially of types IIA/X and I fibers, and denervation for an extended period (4 weeks) produces a severe myopathy similar to what is observed in 9- to 10-month-old TSC1mKO mice37. This evidence concerns the gene RPTOR and myopathy.