Ki-67 is one of the most commonly used tumor markers for studying cellular proliferation, and its expression in OSCC was examined in many previous studies that showed similar results to that of the current study, as high Ki-67 expression was mostly associated with adverse clinicopathological parameters such as histological tumor grade, tumor extent, nodal metastasis, TNM stage, and lymphovascular invasion (32,33). Here, MKI67 is linked to neoplasm.