KRAS and neoplasm: In addition, in this study, several clinical and pathological indicators of the tumor progression, such as tumor extent, nodal metastasis, distant metastasis, pathological stage, and lymphovascular invasion, have been related to KRAS expression, indicating that this protein expression may be closely associated with occurrence and development of OSCC, and it may be hypothesized that increased KRAS expression promotes OSCC invasion and metastasis.