High KRAS expression was significantly associated with poorly differentiated OSCC (grade 3; P<0.001), higher tumor extent (P=0.001), the presence of nodal (P≤0.001) and distant metastasis (P=0.009), higher pathological stage (P<0.001), and the presence of lymphovascular invasion (P<0.001). This evidence concerns the gene KRAS and neoplasm.