FGFR4 and hepatocellular carcinoma: The combination of FGFR4 specific inhibitors combined with Parthenolide was found to be the most effective strategy for the treatment of FGFR4 positive HCC patients, which was supported by the effectively 3D cell spheroid experiment evaluation and mechanism exploration, after we obtained the effect of FGFR4 specific inhibitors FGF401 and BLU-554 combined with seven candidate drugs.