Figure 7A showed that the levels of p-AKT and p-ERK were significantly decreased by FGF401 or BLU-554 in combination with Parthenolide compared with single drug or no drug effects. And we speculated the increased effect of the combined scheme might be attributed to the synergistic suppression of the MAPK-ERK and PI3K-AKT pathways, which regulate HCC cell survival and proliferation (Figure 7B). Here, AKT1 is linked to hepatocellular carcinoma.