Metabolism-related pathways (pathways in cancer, metabolic pathways, MAPK signaling pathway, congenital disorders of metabolism, and PI3K-Akt signaling pathway) and immunity-related pathways (immune system diseases, primary immunodeficiency, IL-17 signaling pathway, complement and coagulation cascades, and cytokine-cytokine receptor interaction) were significantly enriched across the pairwise comparisons among the three groups (Figure 2A). This evidence concerns the gene AKT1 and inborn error of immunity.