Moreover, FGF19, ADCY8 and KRT17 were involved in biological processes such as regulation of actin cytoskeleton, pathways in cancer, MAPK signaling pathway, dilated cardiomyopathy, chemokine signaling pathway, purine metabolism gnrh signaling pathway, estrogen signaling pathway and congenital malformations (Figure 4C), all of which are related to immunological disturbances and metabolic disorders. This evidence concerns the gene ADCY8 and metabolic disease.