Interestingly, several previous studies have highlighted that a decrease in NFKB1 expression in response to M. tuberculosis and M. bovis infection is directly related to suppression of the host innate immune signaling as well as prevention of phagosome maturation in the chronic stages of bTB and TB (MacHugh et al., 2009; Alam et al., 2019). The gene discussed is NFKB1; the disease is tuberculosis.