NFKB1 and Sepsis: Moreover, overactivity of the NF-κB and IL-17 signaling pathways in response to mycobacterial infection leads to the induction of pyroptosis which is a highly inflammatory form of lytic programmed cell death, thereby facilitating the spread of mycobacteria to neighboring cells (Beckwith et al., 2020) as well as severe TB sepsis (Li L.-L.