CDKN1A and tuberculosis: In addition to BCL2L1, the CDKN1A hub-central gene encodes the p21 protein, a member of the Cip/Kip family, whose high levels are associated with pulmonary sarcoidosis and, as an inhibitor of apoptosis, facilitate the formation and maturation of TB granulomas (Xaus et al., 1999, 2003; Silva et al., 2021).