We infected BMDMs of C57BL/6, Gsdmd−/−, Casp8/RIPK3−/−, and Casp8+/+/RIPK3−/− mouse strains with B. abortus, and after 17 h of infection, we evaluated the secretion of IL-1β in the supernatant of the cells. The gene discussed is CASP8; the disease is infection.