NPM1 and acute promyelocytic leukemia: Indeed, mutations in the NPM1 gene has been observed in Anaplastic large-cell lymphoma (ALCL), Acute promyelocytic leukemia (APL) and Acute myeloid leukemia (Pandolfi, 1996; Yoneda-Kato et al., 1996; Grisendi et al., 2006; Kunchala et al., 2017).