Previous in vitro experiments have shown that bile acids induce Glut4 transcription in 3T3-L1 and HepG2 cells (Shen et al., 2008), and bile acids also increase GLUT4 expression in Zucker (fa/fa) rats, thereby ameliorating insulin resistance (Cipriani et al., 2010). The gene discussed is SLC2A4; the disease is Insulin resistance.