Here we revealed that a missense variant rs12329760 (c.478G>A, p. V160M) in TMPRSS2, which changes the valine residue at amino acid position 160 to a methionine residue, contributed to protection against SARS-CoV-2 infection in medical care workers who had close contact with COVID-19 patients but did not become infected with the virus. The gene discussed is TMPRSS2; the disease is COVID-19.