They have been reported to have both protective and deleterious effects on S. aureus infections, with decreased mortality observed with IFNAR deficient mice in a staphylococcal pneumonia model (Martin et al., 2009; Parker and Prince, 2012; Parker et al., 2014), while an anti-IFNAR1 subunit antibody has been reported to increase lung S. aureus burden (Spolski et al., 2019). Here, IFNAR1 is linked to staphylococcal pneumonia.