PTH1R and lethal chondrodysplasia: PTH1R is located in the region on chromosome 19 associated with lamb metacarpal length and all three adult leg traits, and has been found to be involved in osteoblast development in mice (Qiu et al., 2015), and is associated with skeletal disorders such as Eiken's syndrome (Duchatelet et al., 2005), Jansen's metaphyseal chondrodysplasia and Blomstrand's lethal chondrodysplasia (Schipani & Provot, 2003).