Additionally, some cytokines and chemokines may also participate in this process, since M2 TAMs also secrete IL-8, IL-10, TGF-β, CCL2, CCL4, CXCL13, and other soluble mediators that are capable of inducing tumor growth in vitro and in vivo (98, 117, 121–125). This evidence concerns the gene IL10 and neoplasm.