SAMHD1 and infection: To rule out the impact of endogenous SAMHD1 and accentuate the antiviral activities of SAMHD1 truncations and mutants, we transfected plasmids expressing SAMHD1 truncations and mutants in SAMHD1-KO Huh7.5.1 cells followed by infection with JFH1 HCVcc.