Based on the above conjecture, we co-transfected the SAMHD1 and SREBP1 plasmids in Huh7.5.1 cells or SAMHD1-KO Huh7.5.1 cells followed by infection with JFH1 HCVcc to observe whether the inhibitory effect of SAMHD1 on HCV changed. The gene discussed is SREBF1; the disease is infection.