IL10 and neoplasm: In addition, pro-tumor immune cells and immunosuppressive factors (e.g., transforming growth factor β, interleukin-10) act synergistically to exert important immunosuppressive effects, including inhibition of differentiation and maturation of DCs, inhibition of NK cell toxicity, inhibition of antigen presentation, inactivation of the pro-apoptotic pathway, and disturbance of T cell receptor signaling (25) (Figure 1).