RT upregulated the expression of genes containing immunogenic mutations in a mouse model of triple-negative breast cancer with poor immunogenicity and increased tumor cell surface death receptors Fas and DR5, with the result that neoantigen-specific CD8+ T cells and CD4+ T cells preferentially killed irradiated tumor cells as well as promoted epitope spreading (203). The gene discussed is TNFRSF10B; the disease is neoplasm.