CXCR2 and malignant colon neoplasm: As stated in the research, in an in vivo CRC mouse model, blocking the CXCL8–CXCR2 axis can decrease functional CD8+ T cell and DC infiltration into tumor sites, leading to the opposite effect of antitumor immunity, indicating that expression of CXCL8 is related to the infiltration of CD8+ T cells in colon cancer, and the process is completed by CXCL8–CXCR2 pathways and DC activation (28).