Finally, at T0 a higher plasma level of CD40L in both the depleting/sequestering-out and the enriching-in subgroups compared to HD was observed (the depleting/sequestering-out: 101855 [73681-129802] and 26664 [12457-55197] pg/ml, respectively, p=0.0013; the enriching-in: 125967 [101016-140260] and 26664 [12457-55197] pg/ml, respectively, p=0.0012) (Figure 4E). This evidence concerns the gene CD40LG and Huntington disease.