Next, our data showed that macrophage-IL1B (sub-cluster 0) in tumor cell high tumor infiltration group not only displayed a lower proportion (Figure 5C), but also strikingly lacked the expression of MHC molecules, inflammatory cytokines and chemokines compared to the corresponding sub-cluster in low tumor infiltration group (Supplementary Figure 4B). The gene discussed is IL1B; the disease is neoplasm.