Compared to HD, Cluster 0, Cluster 1 and Cluster 12 mainly appear in MM patients, especially Cluster 0 and Cluster 1(Figure 1C).We annotated seven cell types based on the expression of characteristic genes of these clusters: hematopoietic stem and progenitor cells (HSPC) (CD34 and AVP), T/NK cells (CD3E and KLRF1), myeloid (LYZ and CST3), neutrophils (LYZ, CTS3, CSF3R, AZU1 and MPO), plasma/MM cells (SDC1, TNFRSF17 and CD38), B cells (MA4A1, CD79A and CD79B), Erythroidblast (ALAS2, AHSP and GYPA) (Figures 1D, E). This evidence concerns the gene ALAS2 and Miyoshi myopathy.