Furthermore, CAV-1 expression was significantly reduced in aggressive types (micronodular, infiltrative, and metatypical BCC) compared to non-aggressive types (nodular and superficial BCC) of BCC, suggesting that CAV-1 expression levels could reflect the biological behavior of BCC and aid in the detection of high-risk patients with poor prognosis (40). This evidence concerns the gene CAV1 and skin basal cell carcinoma.