CAV1 and neoplasm: In contrast, increased CAV-1 expression has been reported in moderate to severe prostate cancer (118), bladder cancer correlating with tumor grade and metastasis (119), metastatic renal cancer (120), and moderate to severe SCC of the oral cavity (moderate to severe), larynx, oropharynx, hypopharynx, esophagus (metastatic), and cervix (low grade) (121–124).