reported that CAV-1 overexpression in a human melanoma cell line resulted in decreased cell growth and motility (129), and other groups reported that high CAV-1 expression in stromal cells and melanoma cells was associated with longer survival in cMM patients with lymph node metastasis (130), and CAV-1 overexpression suppressed subcutaneous tumor growth (131). Here, CAV1 is linked to metastatic malignant neoplasm in the lymph nodes.