POLA2 and acute lymphoblastic leukemia: The upregulated genes in B-ALL Trm-like cells included proliferation-related genes, POLA2, MCM2, and TFDP1, exhaustion-related genes, PDCD1, LAG3, HAVCR2, TIGIT, and TOX, and T-cell activation-related genes, CSK and CD27. The GO and KEGG enrichment results showed that the enriched functions and signaling pathways were related to both cell proliferation and apoptosis, such as “regulation of mitotic cell cycle phase transition,” “leukocyte apoptotic process,” “Cell cycle,” “Apoptosis,” and “DNA replication” (Figure 2B).