Compared to Trm-like cells of healthy individuals, the DEG analysis revealed a high expression of chemokine receptors (CCR1, CCR3, CX3CR1, CXCR6, CCR5, and ACKR3) and selectins (SELP) and low expression of integrins (CD69, ITGA4, ITGAL, ITGB7, and ITGA1) and sphingosine-1-phosphate (S1P) receptors (S1PR1 and S1PR5) in both CD4+ and CD8+ Trm-like cells of B-ALL patients, which were responsible for the regulation of T-cell migration (48) (Figure 2E). The gene discussed is S1PR5; the disease is precursor B-cell acute lymphoblastic leukemia.