Other pathways involved in the stress response such as ROS pathway, Interferon alpha and gamma response, PI3K AKT mTOR signaling, UPR pathway and p53 pathways were also elevated in classical monocyte, NK cells, activated CD4+ T cells, Class-switched memory B cells and CD4+ central memory T cells in the active COVID-19 patients. Here, TP53 is linked to COVID-19.