We found immune response related pathways (TGF-β, IL2-STAT5, IL6-JAK-STAT3, and TNFα signaling, Complement system activation, and Inflammatory response pathway) to be upregulated in the classical monocyte, NK cells, activated CD4+ T cells and CD4+ central memory T cells in active COVID-19 patients. This evidence concerns the gene STAT3 and COVID-19.