TP53 and COVID-19: On the other hand, the stress response related pathways (ROS pathway, Interferon alpha and gamma response, PI3K–AKT-mTOR signaling, UPR and p53 pathways) were also particularly enriched in the Classical monocyte, NK cells, activated CD4+ T cells, Class-switched memory B cells and CD4+ central memory T cells of the COVID-19 positive patients.